The heat-transfer method (HTM)
Principle of the heat-transfer method. An aluminum chip is coated with a functional interface, depending on the application. The chip is heated by means of a copper heat sink by means of a heater and its temperature is controlled by a thermocouple and thermostat. The temperature in a liquid flow cell above the chip is monitored in time making it possible to continuously screen the heat-transfer resistance of the interface. Picture of the measuring cell, HTM-unit and a laptop for driving the system and read out the data. Possible applications: DNA mutation detection, Cell detection (Principle: cell capturing by surface imprinted polymers (SIP, synthetic cell receptor) blocking the heat flow through the chip), Small molecule detection, Phase transition study in thiol molecules.